Fig. 1 · Structure
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Thalidomide-Piperazine 5-fluoride hydrochloride
E3 Ubiquitin Ligase Ligand
Thalidomide-Piperazine 5-fluoride hydrochloride is an E3 ubiquitin ligase ligand derived from the CRBN inhibitor Thalidomide. This compound is utilized in the development of proteolysis targeting chimeras (PROTACs), enabling specific modulation of protein degradation pathways. Its unique structure facilitates selective engagement with the ubiquitin-proteasome system, making it valuable for research in targeted therapy and cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2222114-23-8 |
| Applications | E3 Ubiquitin Ligase Ligand |
| Formula | C17H18ClFN4O4 |
| Molecular Weight | 396.80 |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC(F)=C(N4CCNCC4)C=C3C2=O)=O)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.