Fig. 1 · Structure
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Thalidomide-propargyl
Cereblon Ligand
Thalidomide-propargyl is a thalidomide-derived ligand that selectively targets Cereblon (CRBN) for protein recruitment. This compound is instrumental in the development of immunomodulatory drug (IMiD) based PROTACs, facilitating targeted protein degradation. Additionally, Thalidomide-propargyl features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it a valuable tool for click chemistry applications in chemical biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2098487-39-7 |
| Applications | Cereblon Ligand |
| Formula | C16H12N2O5 |
| Molecular Weight | 312.28 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCC#C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.