Fig. 1 · Structure
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Thianthrene
PTR1 Inhibitor
Thianthrene is a selective inhibitor of Leishmania donovani pteridine reductase 1 (PTR1), demonstrating potent inhibitory activity against intracellular amastigotes of Leishmania donovani with an IC50 of 23 μM. This sulfur-containing tricyclic compound is also noted for its moderate anthelmintic properties. Additionally, Thianthrene may interfere with RNA function and protein synthesis, and it has been shown to stimulate liver regeneration in vivo. Its diverse biological activities make Thianthrene a valuable compound for research in parasitology and regenerative medicine.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 92-85-3 |
| Applications | PTR1 Inhibitor |
| Formula | C12H8S2 |
| Molecular Weight | 216.33 |
| SMILES | C12=CC=CC=C1SC3=C(C=CC=C3)S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.