Fig. 1 · Structure
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Thioacetamide
Indirect hepatotoxin
Thioacetamide (TAA) is classified as an indirect hepatotoxin that primarily targets liver parenchymal cells, leading to necrosis. Its bioactivation occurs through the cytochrome P450 enzyme CYP2E1, converting TAA to reactive metabolites such as thioacetamide-S-oxide and thioacetamide-S-dioxide. These metabolites covalently interact with proteins and lipids, resulting in oxidative stress and centrilobular necrosis. Thioacetamide is widely used in research to model liver diseases, including chronic liver fibrosis and hepatic encephalopathy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 62-55-5 |
| Applications | Indirect hepatotoxin |
| Formula | C2H5NS |
| Molecular Weight | 75.13 |
| Synonyms | Acetothioamide; TAA; Thiacetamide |
| SMILES | CC(N)=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.