Fig. 1 · Structure
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Thioperamide
H3 Antagonist
Thioperamide is a selective H3 receptor antagonist that effectively inhibits [3H]histamine release with a Ki of 4.3 nM. This compound also reduces [3H]histamine synthesis, showing inhibition at a Ki of 31 nM. Due to its oral bioavailability and ability to penetrate the blood-brain barrier, thioperamide is valuable for research applications related to neuropharmacology and histaminergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 106243-16-7 |
| Applications | H3 Antagonist |
| Formula | C15H24N4S |
| Molecular Weight | 292.44 |
| Synonyms | MR-12842 |
| SMILES | S=C(N1CCC(C2=CN=CN2)CC1)NC3CCCCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.