Fig. 1 · Structure
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Thr101
PMI Inhibitor
Thr101 is a selective inhibitor of phosphomannose isomerase (PMI) with an IC50 of 2.9 μM. By targeting PMI, Thr101 disrupts the conversion of mannose-6-phosphate (Man-6-P) to fructose-6-phosphate (Fru-6-P), without affecting phosphomannose mutase 2 (PMM2). This compound is valuable in research related to congenital disorder of glycosylation type Ia (CDG-Ia), providing insights into the biochemical pathways involved in this condition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 727664-79-1 |
| Applications | PMI Inhibitor |
| Formula | C14H10FNOS |
| Molecular Weight | 259.30 |
| SMILES | O=C1N(SC2=CC(F)=CC=C12)C3=CC=CC=C3C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.