Fig. 1 · Structure
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Thymine
DPD Inhibitor
Thymine, a fundamental pyrimidine base in DNA, serves as a substrate for dihydropyrimidine dehydrogenase (DPD) in rat liver, exhibiting a Km value of 2.2 μM and a Ki of 24 μM when utilizing 5-FU as a substrate. With a specific activity of 0.68 nmol/min/mg, thymine plays a crucial role in nucleic acid metabolism and is relevant in studies focusing on cancer and pharmacogenomics where DPD activity impacts drug metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 65-71-4 |
| Applications | DPD Inhibitor |
| Formula | C5H6N2O2 |
| Molecular Weight | 126.11 |
| SMILES | O=C1NC(C(C)=CN1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.