Fig. 1 · Structure
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Thyrotropin
Thyroid-Stimulating Hormone
Thyrotropin (TSH) is a key thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. It regulates thyroid endocrine function by activating the Tshr/Gαq/PKC signaling pathway, leading to transcriptional regulation of TH-gatekeeper genes in tanycytes and inhibiting apoptosis. Research indicates that low levels of thyrotropin are associated with increased bone remodeling, reduced bone mass, and a heightened fracture risk in animal models. This makes thyrotropin a valuable tool for studying skeletal remodeling and hyperthyroidism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 9002-71-5 |
| Applications | Thyroid-Stimulating Hormone |
| Synonyms | TSH; Pretiron |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.