Fig. 1 · Structure
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TI17
Trip13 Inhibitor
TI17 is a potent inhibitor of the thyroid hormone receptor-interacting protein Trip13, exhibiting significant anticancer properties. It effectively suppresses cell proliferation in multiple myeloma (MM) while inducing cell cycle arrest and apoptosis. By targeting Trip13, an AAA-ATPase crucial for double-strand break (DSB) repair, TI17 disrupts its function, leading to enhanced DNA damage and potential therapeutic applications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1005178-02-8 |
| Applications | Trip13 Inhibitor |
| Formula | C23H22N2O3 |
| Molecular Weight | 374.43 |
| SMILES | OC(C1C2C=CC(C1C(NC3=CC=C(C=C3)CC4=CC=NC=C4)=O)C5CC25)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.