Tiagabine-d5 hydrochloride is a deuterium-labeled derivative of Tiagabine hydrochloride, primarily functioning as a selective GABA reuptake inhibitor. It exhibits potent anticonvulsant properties, with IC50 values of 67 nM, 446 nM, and 182 nM for [3H]GABA uptake in synaptosomes, neurons, and glial cells, respectively. This stable isotope form is valuable for pharmacokinetic studies and metabolic profiling in research applications focused on GABAergic neurotransmission and seizure disorders.
Tiagabine-d5 hydrochloride is a deuterium-labeled derivative of Tiagabine hydrochloride, primarily functioning as a selective GABA reuptake inhibitor. It exhibits potent anticonvulsant properties, with IC50 values of 67 nM, 446 nM, and 182 nM for [3H]GABA uptake in synaptosomes, neurons, and glial cells, respectively. This stable isotope form is valuable for pharmacokinetic studies and metabolic profiling in research applications focused on GABAergic neurotransmission and seizure disorders.
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