Fig. 1 · Structure
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Tiazofurin
IMP Dehydrogenase Inhibitor
Tiazofurin is a synthetic nucleoside analogue that acts as an inhibitor of inosine monophosphate dehydrogenase (IMPDH). It is metabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), leading to its antineoplastic effects. Tiazofurin has been shown to enhance interleukin-6 (IL-6) autosecretion in K562 cells and exhibits anti-orthopoxvirus and anti-variola activities. This compound is valuable for research in leukemia and lung cancer studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 60084-10-8 |
| Applications | IMP Dehydrogenase Inhibitor |
| Formula | C9H12N2O5S |
| Molecular Weight | 260.27 |
| Synonyms | NSC 286193; Riboxamide |
| SMILES | O=C(N)C1=CSC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.