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Tipepidine citrate

Non-narcotic Antitussive Agent

Tipepidine citrate is a non-narcotic antitussive agent that inhibits dopamine D2 receptor-mediated GIRK current, effectively activating ventral tegmental area (VTA) dopamine neurons with an IC50 of 7.0 μM for IDA(GIRK). This compound demonstrates additional biological activities, including the activation of AMP-activated protein kinase (AMPK) and exhibiting antidepressant-like effects. Tipepidine citrate has also been shown to enhance the analgesic effect of carbamazepine and to improve metabolic parameters such as adipose tissue fibrosis and glucose intolerance in models of obesity induced by a high-fat diet.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	14698-07-8
Applications	Non-narcotic Antitussive Agent
Formula	C₂₁H₂₅NO₇S₂
Molecular Weight	467.56
SMILES	CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.O=C(CC(C(O)=O)(O)CC(O)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.