Fig. 1 · Structure
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Tipepidine
IDA(GIRK) Inhibitor
Tipepidine is an inhibitor of the dopamine D2 receptor-mediated G-protein coupled inwardly rectifying potassium (GIRK) currents, exhibiting a half-maximal inhibitory concentration (IC50) of 7.0 μM. By inhibiting these currents, Tipepidine activates ventral tegmental area (VTA) dopamine neurons, thereby influencing dopaminergic signaling. This compound has demonstrated potential antidepressant-like effects and is commonly studied in research related to neuropharmacology and respiratory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 5169-78-8 |
| Applications | IDA(GIRK) Inhibitor |
| Formula | C15H17NS2 |
| Molecular Weight | 275.43 |
| SMILES | CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.