TIY-7 is a selective and orally active inhibitor of tropomyosin receptor kinases (TRKs). It demonstrates potent enzyme inhibition with IC50 values of 2.9 nM for TRKA and as low as 0.2 nM for TRKCG696A, showcasing its efficacy against various TRK mutations. TIY-7 exhibits significant anti-tumor activity in mouse xenograft models, making it a valuable tool for research in cancer biology and targeted therapy development.
TIY-7 is a selective and orally active inhibitor of tropomyosin receptor kinases (TRKs). It demonstrates potent enzyme inhibition with IC50 values of 2.9 nM for TRKA and as low as 0.2 nM for TRKCG696A, showcasing its efficacy against various TRK mutations. TIY-7 exhibits significant anti-tumor activity in mouse xenograft models, making it a valuable tool for research in cancer biology and targeted therapy development.
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