Fig. 1 · Structure
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TK216
ETS/EWS-FLI1 Inhibitor
TK216 is a potent E26 transformation specific (ETS) inhibitor that exhibits oral bioavailability. It directly targets and binds to the EWS-FLI1 fusion protein, disrupting its interactions with RNA helicase A. By inhibiting EWS-FLI1 functionality, TK216 demonstrates significant anticancer activity, making it a valuable reagent for research in therapeutic strategies against Ewing sarcoma and related malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1903783-48-1 |
| Applications | ETS/EWS-FLI1 Inhibitor |
| Formula | C19H15Cl2NO3 |
| Molecular Weight | 376.23 |
| SMILES | O=C1NC2=C(C(Cl)=CC=C2Cl)C1(CC(C3=CC=C(C4CC4)C=C3)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.