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TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1?C1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.12 mL | 105.59 mL | 211.18 mL |
| 0.5 mM | 4.22 mL | 21.12 mL | 42.24 mL |
| 1 mM | 2.11 mL | 10.56 mL | 21.12 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 473.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21531 |
|---|---|
| CAS No. | 152684-53-2 |
| Formula | C23H27N3O6S |
| M. Wt | 473.54 |
| Purity | >98% |
| Synonyms | TLK-117, TLK 117, TER117, TER-117, TER 117 |
| SMILES | O=C(O)[[email protected]@H](C1=CC=CC=C1)NC([[email protected]@H](NC(CC[[email protected]](N)C(O)=O)=O)CSCC2=CC=CC=C2)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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