TLR2/9 antagonist 1

Catalog No.: A35392
TLR2/9 Antagonist
TLR2/9 Antagonist 1 is a reversible covalent antagonist targeting Toll-like receptors 2 and 9, with IC₅₀ values of 0.5 μM for TLR2/TLR6, 0.6 μM for TLR2/TLR1, and 0.32 μM for TLR9. This compound selectively inhibits TLR2 and TLR9 without significant effects on other TLR subtypes. TLR2/9 Antagonist 1 is valuable for investigating inflammation-related pathology in central nervous system diseases and malignancies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTLR2/9 Antagonist 1 is a reversible covalent antagonist targeting Toll-like receptors 2 and 9, with IC₅₀ values of 0.5 μM for TLR2/TLR6, 0.6 μM for TLR2/TLR1, and 0.32 μM for TLR9. This compound selectively inhibits TLR2 and TLR9 without significant effects on other TLR subtypes. TLR2/9 Antagonist 1 is valuable for investigating inflammation-related pathology in central nervous system diseases and malignancies.
Product Information
Catalog NumA35392
FormulaC19H18FNO2
Molecular Weight311.35
CAS Number2377679-85-9
SMILESO=CC1=C(C(F)=CC(/C=C/C2=CC=C(C=C2)N3CCCC3)=C1)O
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