TLR2/9 Antagonist 1 is a reversible covalent antagonist targeting Toll-like receptors 2 and 9, with IC₅₀ values of 0.5 μM for TLR2/TLR6, 0.6 μM for TLR2/TLR1, and 0.32 μM for TLR9. This compound selectively inhibits TLR2 and TLR9 without significant effects on other TLR subtypes. TLR2/9 Antagonist 1 is valuable for investigating inflammation-related pathology in central nervous system diseases and malignancies.
TLR2/9 Antagonist 1 is a reversible covalent antagonist targeting Toll-like receptors 2 and 9, with IC₅₀ values of 0.5 μM for TLR2/TLR6, 0.6 μM for TLR2/TLR1, and 0.32 μM for TLR9. This compound selectively inhibits TLR2 and TLR9 without significant effects on other TLR subtypes. TLR2/9 Antagonist 1 is valuable for investigating inflammation-related pathology in central nervous system diseases and malignancies.
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