TLR9 antagonist 2

Catalog No.: A35395
TLR9 Antagonist
TLR9 Antagonist 2 is a highly selective antagonist that targets Toll-like receptor 9 (TLR9), demonstrating an IC50 of 13 nM against human TLR9. This compound effectively inhibits the CpG-induced production of the pro-inflammatory cytokine IL-6. TLR9 Antagonist 2 is valuable for research into systemic inflammation mediated by TLR9, including studies focused on conditions like sepsis.
Grouped product items
Size Price Stock Qty
25mg
$1,530.00
In stock
50mg
$1,950.00
In stock
100mg
$2,480.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTLR9 Antagonist 2 is a highly selective antagonist that targets Toll-like receptor 9 (TLR9), demonstrating an IC50 of 13 nM against human TLR9. This compound effectively inhibits the CpG-induced production of the pro-inflammatory cytokine IL-6. TLR9 Antagonist 2 is valuable for research into systemic inflammation mediated by TLR9, including studies focused on conditions like sepsis.
Product Information
Catalog NumA35395
FormulaC25H36N6O2
Molecular Weight452.60
CAS Number1351978-48-7
SMILESOCCN1CCN(C=2C=CC(=CC2)C3=NC=C4C(=N3)N(CC4)CCCN5CCOCC5)CC1
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