Fig. 1 · Structure
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TM-1
PDHK Inhibitor
TM-1 is a selective inhibitor of pyruvate dehydrogenase kinase (PDHK1 and PDHK2), demonstrating IC50 values of 2.97 μM and 5.2 μM, respectively. By inhibiting PDHK activity, TM-1 effectively prevents the phosphorylation of the pyruvate dehydrogenase complex (PDHC), leading to enhanced cellular energy metabolism. This compound is utilized in research focused on cancer biology and metabolic regulation, particularly in studies addressing cell proliferation and metabolic adaptation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 921099-13-0 |
| Applications | PDHK Inhibitor |
| Formula | C26H32N2O6 |
| Molecular Weight | 468.54 |
| SMILES | O=C1C(C2=CC=C(OC)C(OC)=C2)=C(C)C3=CC=C(OCCN4CCN(CCO)CC4)C=C3O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.