Fig. 1 · Structure
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TM6008
PHD Inhibitor
TM6008 is a potent prolyl hydroxylase (PHD) inhibitor that demonstrates oral bioactivity. This compound chelates transition metals, specifically copper, and inhibits ascorbic acid autoxidation with an IC50 value of 0.57 μM. TM6008 provides protective effects against ischemic injury in vivo, making it a valuable tool for research in cerebrovascular diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 945008-17-3 |
| Applications | PHD Inhibitor |
| Formula | C21H17N5O3 |
| Molecular Weight | 387.39 |
| SMILES | O=C1N(C)C(C(C(C2=CC(C3=NC=CC=C3)=NC4=CC=CC=C24)=O)=C(N)N1C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.