TMX-3013 is a selective inhibitor of cyclin-dependent kinases (CDKs), effectively targeting CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM, respectively. This reagent is valuable for research involving cell cycle regulation and cancer therapeutics. Additionally, TMX-3013 can be employed in the synthesis of PROTACs that utilize a polyethylene glycol (PEG) linker and Thalidomide as a cereblon (CRBN) recruiting moiety.
Fig. 1 · Structure
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TMX-3013
CDKs Inhibitor
TMX-3013 is a selective inhibitor of cyclin-dependent kinases (CDKs), effectively targeting CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM, respectively. This reagent is valuable for research involving cell cycle regulation and cancer therapeutics. Additionally, TMX-3013 can be employed in the synthesis of PROTACs that utilize a polyethylene glycol (PEG) linker and Thalidomide as a cereblon (CRBN) recruiting moiety.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2488761-18-6 |
| Applications | CDKs Inhibitor |
| Formula | C17H14BrFN6O3S |
| Molecular Weight | 481.30 |
| SMILES | NC(C1=C(C=CC=C1NC2=NC(NC3=CC=C(C=C3)S(N)(=O)=O)=NC=C2Br)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.