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TMX-4140

PIP4K2C Ligand

TMX-4140 is a selective inhibitor of PIP4K2C, demonstrating a KD value of 7.2 nM, indicating strong affinity for PIP4K2C compared to PIP4K2B. This compound plays a crucial role in modulating phosphoinositide metabolism and is valuable in the development of PROTACs, such as TMX-4153, for targeted protein degradation research. Researchers can employ TMX-4140 to explore the biological functions of PIP4K2C and its potential therapeutic implications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2867519-51-3
Applications	PIP4K2C Ligand
Formula	C₂₅H₂₀ClN₅O
Molecular Weight	441.91
SMILES	ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N5CCCC5=O)=CN=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.