Fig. 1 · Structure
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TNKS-IN-2
TNKS Inhibitor
TNKS-IN-2 is a potent and selective inhibitor of tankyrase (TNKS), exhibiting pIC50 values of 8.1 and 7.0 for TNKS and Wnt, respectively. This compound effectively modulates the Wnt signaling pathway by targeting TNKS, making it a valuable tool for research involving cellular growth and differentiation. TNKS-IN-2 is useful for studies investigating the role of tankyrases in cancer biology and other diseases associated with altered Wnt signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1584646-59-2 |
| Applications | TNKS Inhibitor |
| Formula | C24H22N10O2 |
| Molecular Weight | 482.50 |
| SMILES | O=C(N1CCN(CC1)C(C2=CC=C(C=C2)NC3=NC4=C(C=CC=C4)N5C3=NN=N5)=O)C6=NN(C=C6)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.