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TNKS-IN-4

Tankyase Inhibitor

TNKS-IN-4 is a potent tankyrase (TNKS) inhibitor, exhibiting IC50 values of 0.1 nM for TNKS1 and 7.6 nM for TNKS2. This compound plays a critical role in the modulation of Wnt signaling pathways and has been leveraged in research focused on APC-mutant colorectal cancer. TNKS-IN-4 facilitates investigations into tumorigenesis and provides insights into therapeutic strategies targeting tankyrase activity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1507362-06-2
Applications	Tankyase Inhibitor
Formula	C₂₄H₂₄N₄O₃S
Molecular Weight	448.54
SMILES	O=C1C2=CC=CC=C2NC(SCCC(N[C@@H]3CC[C@@H](OC4=CC=C(C#N)C=C4)CC3)=O)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.