Fig. 1 · Structure
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TNKS1/2-IN-1
TNKS1/2 Inhibitor
TNKS1/2-IN-1 is a potent inhibitor of tankyrase 1 and 2, demonstrating pIC50 values between 7.1 and 8.2. This compound effectively modulates the activity of TNKS1/2, making it a valuable tool for research into cancer, fibrosis, and other hyperproliferative diseases. Its selective inhibition offers insights into the biological pathways regulated by tankyrases, facilitating the exploration of therapeutic strategies targeting these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1498300-31-4 |
| Applications | TNKS1/2 Inhibitor |
| Formula | C26H23F4N3O4 |
| Molecular Weight | 517.47 |
| SMILES | O=C(N1C[C@H]2CC[C@H](C(O)=O)CC2)N(CC3=CC=CC(C(F)(F)F)=C3C#N)C4=CC=C(F)C(C)=C4C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.