Fig. 1 · Structure
Documents & Downloads
TNKS1/2-IN-2
Tankyrases Inhibitor
TNKS1/2-IN-2 is a potent inhibitor of tankyrases, specifically targeting TNK1 and TNK2 with IC50 values of 4 nM and 63 nM, respectively, in enzymatic assays. This compound effectively inhibits the proliferation of A549 and H292 cell lines, demonstrating IC50 values of 39.5 nM and 12.8 nM. TNKS1/2-IN-2 is valuable for research applications focused on cancer, providing insights into tankyrase-related pathways and their influence on tumor growth.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1498300-35-8 |
| Applications | Tankyrases Inhibitor |
| Formula | C26H24F3N3O4 |
| Molecular Weight | 499.48 |
| SMILES | O=C(N(C1=O)C[C@@H]2CC[C@H](CC2)C(O)=O)C(C(N1CC3=C(C(C(F)(F)F)=CC=C3)C#N)=CC=C4)=C4C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.