Fig. 1 · Structure
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Tofacitinib-d3 citrate
Stable Isotope
Tofacitinib-d3 citrate is a deuterated form of Tofacitinib citrate, serving as a stable isotope labeling reagent. This compound functions as a selective inhibitor of Janus kinases (JAK1, JAK2, and JAK3) with IC50 values of 1 nM, 20 nM, and 112 nM, respectively. Tofacitinib citrate exhibits significant antibacterial, antifungal, and antiviral activities, making it valuable for studies in immunology, infectious disease, and pharmacology. Its isotopic labeling allows for precise tracking and quantification in biological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2701680-77-3 |
| Applications | Stable Isotope |
| Formula | C22H25D3N6O8 |
| Molecular Weight | 507.51 |
| Synonyms | Tasocitinib-d3 citrate; CP-690550-d3 citrate |
| SMILES | O=C(CC#N)N1C[C@H](N(C2=C3C(NC=C3)=NC=N2)C([2H])([2H])[2H])[C@H](C)CC1.O=C(CC(C(O)=O)(O)CC(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.