Fig. 1 · Structure
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Tofersen sodium
Antisense Oligonucleotide
Tofersen sodium is an antisense oligonucleotide that specifically induces RNase H-mediated degradation of superoxide dismutase 1 (SOD1) mRNA, leading to decreased SOD1 protein synthesis. This compound is primarily utilized in research related to amyotrophic lateral sclerosis (ALS), providing insights into the pathophysiology and potential therapeutic strategies targeting SOD1 mutations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1898254-60-8 |
| Applications | Antisense Oligonucleotide |
| Formula | C230H298N72Na19O123P19S15 |
| Molecular Weight | 7128 (free acid) |
| Synonyms | BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.