Fig. 1 · Structure
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Tofersen
Antisense Oligonucleotide
Tofersen is an antisense oligonucleotide designed to induce RNase H-mediated degradation of superoxide dismutase 1 (SOD1) mRNA, thereby decreasing SOD1 protein synthesis. This compound serves as a valuable tool in the study of amyotrophic lateral sclerosis (ALS) pathology and therapeutic interventions targeting SOD1 mutations. Researchers can utilize Tofersen to explore its potential effects on motor neuron preservation and neurodegeneration associated with ALS.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2088232-70-4 |
| Applications | Antisense Oligonucleotide |
| Molecular Weight | 7128.00 |
| Synonyms | BIIB067; ISIS-SOD1Rx; ISIS 333611 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.