Fig. 1 · Structure
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Tolvaptan phosphate ester sodium
Vasopressin Receptor Antagonist
Tolvaptan phosphate ester sodium is a prodrug that functions as a selective vasopressin receptor 2 (V2R) antagonist. It exhibits a competitive inhibition mechanism with an IC50 value of 1.28 μM against arginine vasopressin (AVP)-induced platelet aggregation. This compound is valuable for research into cardiac edema and related conditions, providing insights into the modulation of fluid balance and vascular function through vasopressin signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 942619-79-6 |
| Applications | Vasopressin Receptor Antagonist |
| Formula | C26H24ClN2Na2O6P |
| Molecular Weight | 572.88 |
| SMILES | O=C(C1=C(C)C=CC=C1)NC2=CC=C(C(C)=C2)C(N3C4=CC=C(C=C4C(CCC3)OP(O[Na])(O[Na])=O)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.