Fig. 1 · Structure
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Tominersen
Antisense Oligonucleotide
Tominersen is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA, leading to significant suppression of HTT production. This compound has demonstrated potential in enhancing survival and reducing brain atrophy in mouse models. Tominersen is valuable for research applications focused on Huntington's disease (HD), providing insights into therapeutic strategies for neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1709886-74-7 |
| Applications | Antisense Oligonucleotide |
| Molecular Weight | 7078.00 |
| Synonyms | RG6042; IONIS-HTTRx |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.