Tonapofylline

Catalog No.: A21328

adenosine A1 receptor antagonist

Tonapofylline

Tonapofylline Chemical Structure

CAS NO. 340021-17-2

Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.

Availability: In stock

Package Price Qty
5 mg
$225.00
10 mg
$388.00
50 mg
$1,150.00
100 mg
$2,300.00
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Biological Activity

Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.01 mL 120.05 mL 240.09 mL
0.5 mM 4.8 mL 24.01 mL 48.02 mL
1 mM 2.4 mL 12 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21328
Actions Antagonist
M. Wt 416.51
Formula C22H32N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 340021-17-2
Synonyms BG 9928
SMILES O=C(O)CCC1(CC2)CCC2(C(N3)=NC(N(CCC)C(N4CCC)=O)=C3C4=O)CC1

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