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Biological Activity
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.45 mL | 117.24 mL | 234.48 mL |
| 0.5 mM | 4.69 mL | 23.45 mL | 46.9 mL |
| 1 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13304 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2302772-05-8 |
| Formula | C24H22N6O2 |
| M. Wt | 426.47 |
| Purity | >98% |
| SMILES | COC(C=C1)=CC=C1C2=CC=C(N=CC(C3=NN=CO3)=C4NCCCN5C=NC=C5)C4=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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