Fig. 1 · Structure
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TopBP1-IN-1
TopBP1 Inhibitor
TopBP1-IN-1 is a selective inhibitor of TopBP1, a key regulator in DNA damage response pathways. This compound demonstrates synergistic effects when used in conjunction with PARP inhibitors, enhancing their antitumor efficacy. TopBP1-IN-1 is applicable in preclinical research focused on cancer biology and the exploration of combinatorial therapeutic strategies aimed at improving treatment outcomes for tumors with DNA repair deficiencies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1212595-23-7 |
| Applications | TopBP1 Inhibitor |
| Formula | C30H34N4O |
| Molecular Weight | 466.62 |
| SMILES | CN1C([C@@H]2[C@]3([H])C[C@@H](N(CC3)C2)CNCC4=CC=C(C=C4)OC)=CC(C5=CC6=C(C=CC=C6)C=C5)=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.