Fig. 1 · Structure
Documents & Downloads
Topi MF-6
Top1 Inhibitor
Topi MF-6 is a potent inhibitor of DNA topoisomerase I (Top1), exhibiting notable cytotoxic effects against gastrointestinal cancer cells. This compound is applicable in cancer research, particularly as an antibody-drug conjugate (ADC) payload, providing a targeted approach to tumor treatment. Its ability to effectively disrupt DNA replication positions Topi MF-6 as a valuable tool in the study of anticancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2944016-96-8 |
| Applications | Top1 Inhibitor |
| Formula | C23H19F2N3O4 |
| Molecular Weight | 439.41 |
| SMILES | CC[C@@](C1=C(CO2)C(N3CC4=C5C6=C(CCC5(F)F)C(N)=CC=C6N=C4C3=C1)=O)(O)C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.