Fig. 1 · Structure
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Topiramate D12
Antiepileptic Agent
Topiramate D12 is a deuterated form of Topiramate, a broad-spectrum antiepileptic agent known for its diverse mechanisms of action. It functions primarily as a GluR5 receptor antagonist while enhancing GABAergic activity, inhibiting kainate/AMPA receptors, and blocking voltage-sensitive sodium and calcium channels. Additionally, Topiramate D12 increases potassium conductance and inhibits carbonic anhydrase, making it useful in the study of seizure disorders and related neurological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1279037-95-4 |
| Applications | Antiepileptic Agent |
| Formula | C12H9D12NO8S |
| Molecular Weight | 351.44 |
| Synonyms | McN 4853 D12; RWJ 17021 D12 |
| SMILES | NS(OC[C@]12[C@](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O2)([H])[C@@]3([H])[C@@](OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])O3)([H])CO1)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.