Fig. 1 · Structure
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Topoisomerase II inhibitor 14
TopII Inhibitor
Topoisomerase II inhibitor 14 is an effective topoisomerase II inhibitor that induces apoptosis and leads to cell cycle arrest in the S and G2-M phases. This compound also demonstrates antioxidant properties by reducing levels of glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO). It is particularly useful in research applications focused on neck squamous cell carcinoma (HNSCC).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 305343-00-4 |
| Applications | TopII Inhibitor |
| Formula | C15H11Cl2N5 |
| Molecular Weight | 332.19 |
| SMILES | NC1=NC(C2=CC=C(Cl)C=C2Cl)N3C4=CC=CC=C4N=C3N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.