Fig. 1 · Structure
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Topoisomerase II inhibitor 3
Topo IIα/β Inhibitor
Topoisomerase II Inhibitor 3 is an acridone derivative that selectively targets and inhibits both Type II DNA topoisomerase isoforms, topo IIα and topo IIβ, with IC50 values of 0.17 μM and 0.23 μM, respectively. This compound effectively induces DNA damage and promotes apoptosis by disrupting mitochondrial membrane potential. It serves as a valuable tool in cancer research and studies related to DNA topology and cellular response to genotoxic stress.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 99140-25-7 |
| Applications | Topo IIα/β Inhibitor |
| Formula | C18H20N4O4 |
| Molecular Weight | 356.38 |
| SMILES | O=C1C2=C(C([N+]([O-])=O)=CC=C2NCCCN(C)C)NC3=C1C=C(O)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.