Fig. 1 · Structure
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Topoisomerase IIα-IN-3
Topo-IIα Inhibitor
Topoisomerase IIα-IN-3 is a selective inhibitor of topoisomerase IIα, functioning as a DNA intercalator. This compound effectively arrests the cell cycle at the G0/G1 phase and promotes apoptosis in various cancer cell lines. It serves as a valuable tool for studying topoisomerase IIα's role in cancer biology and the mechanisms of apoptosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2538528-11-7 |
| Applications | Topo-IIα Inhibitor |
| Formula | C29H20N6O2S |
| Molecular Weight | 516.57 |
| SMILES | O=C(C1=CC2=C(C(C3=CC=C(OC)C=C3)=N1)NC4=C2C=CC=C4)NC5=NN=C(C(N6)=CC7=C6C=CC=C7)S5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.