Fig. 1 · Structure
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TP-004
MetAP2 Inhibitor
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), exhibiting an IC50 of 6 nM. This compound effectively modulates protein maturation processes by inhibiting MetAP2 activity. TP-004 serves as a valuable tool for studying the role of MetAP2 in various biological pathways and disease models, particularly in cancer research and other conditions where protein processing is altered.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1454299-21-8 |
| Applications | MetAP2 Inhibitor |
| Formula | C17H16F3N5O |
| Molecular Weight | 363.34 |
| SMILES | O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.