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TP-9201

GP IIb/IIIa Receptor Antagonist

TP-9201 is a potent antagonist of the glycoprotein (GP) IIb/IIIa receptor, which plays a crucial role in platelet aggregation. By inhibiting the interaction between GP IIb/IIIa and fibrinogen, TP-9201 effectively suppresses platelet aggregation, showing significant activity against adenosine diphosphate (ADP)-induced aggregation in various animal models, including humans (IC50 = 1-3 μM), baboons, and dogs, while demonstrating reduced effectiveness in rabbits and rats. This compound can be utilized in research focused on preventing rethrombosis following arterial thrombolysis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	138297-15-1
Applications	GP IIb/IIIa Receptor Antagonist
Formula	C₄₅H₆₉N₁₇O₁₄S₂
Molecular Weight	1136.26
SMILES	O=C1N2[C@](CCC2)([H])C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(N)=O)=O)NC(C)=O)C(N)=O)=O)CCCNC(N)=N)=O)CC3=CC=C(C=C3)OC)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.