Fig. 1 · Structure
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TPCK
Serine Protease Inhibitor
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone) is a potent serine protease inhibitor that also inhibits the PDK1/Akt signaling pathway. It has demonstrated the ability to modify the E7 protein in proliferating keratinocyte cells. In research applications, TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat models, and influence vascular permeability in inflamed environments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 402-71-1 |
| Applications | Serine Protease Inhibitor |
| Formula | C17H18ClNO3S |
| Molecular Weight | 351.85 |
| Synonyms | L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK |
| SMILES | CC1=CC=C(C=C1)S(N[C@@H](CC2=CC=CC=C2)C(CCl)=O)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.