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TPH1-IN-1

TPH1 Inhibitor

TPH1-IN-1 is a xanthine derivative that functions as a specific inhibitor of tryptophan hydroxylase 1 (TPH1), exhibiting an IC50 value of 110.1 nM. This compound demonstrates robust in vitro activity and is stable in liver microsomes, making it a valuable tool for studies targeting serotonin biosynthesis. TPH1-IN-1 effectively inhibits adipocyte differentiation in T3-L1 cells, highlighting its potential applications in metabolic research and related therapeutic investigations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3040015-86-6
Applications	TPH1 Inhibitor
Formula	C₂₁H₁₈N₆O₄S
Molecular Weight	450.47
SMILES	OC1=CC=C(C(CN2C(C(NC(N3CC)=O)=O)=C3N=C2CC4=CN5C(SC=C5)=N4)=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.