TPMPA is a selective antagonist of the GABAC receptor, exhibiting a binding affinity of KB = 2.1 μM. It does not significantly interact with GABAA or GABAB receptors, with binding constants of KB = 320 μM and EC50 = 500 μM, respectively. This compound is valuable in research focused on modulating orientation selectivity in ganglion cells, making it an important tool for exploring neural signaling mechanisms.
TPMPA is a selective antagonist of the GABAC receptor, exhibiting a binding affinity of KB = 2.1 μM. It does not significantly interact with GABAA or GABAB receptors, with binding constants of KB = 320 μM and EC50 = 500 μM, respectively. This compound is valuable in research focused on modulating orientation selectivity in ganglion cells, making it an important tool for exploring neural signaling mechanisms.
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