Fig. 1 · Structure

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TPPU

Cat. No. A20368 CAS 1222780-33-7

sEH inhibitor

TTPU is a soluble epoxide hydrolase (sEH) inhibitor with IC50 values of 37 and 3.7 nM for monkey and human sEH, respectively.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HepG2 GI50 > 25 μM Cytotoxicity against human HepG2 cells by MTT assay [PMID: 23726028]
Huh-7 GI50 > 25 μM Cytotoxicity against human HuH7 cells by MTT assay [PMID: 23726028]
HUVEC GI50 > 25 μM Antiproliferative activity against HUVEC after 72 hrs by MTT assay [PMID: 23726028]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1222780-33-7
Applications sEH inhibitor
Formula C16H20F3N3O3
Molecular Weight 359.34
SMILES
O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CC)=O)CC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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