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TQ05310

Name: TQ05310
Brand: Adooq Bioscience
SKU: A75805
Availability: OutOfStock

Cat. No. A75805 CAS 2071196-10-4

IDH2 Mutant Inhibitor

TQ05310 is an orally bioavailable inhibitor of IDH2 mutants, specifically targeting IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM). It effectively inhibits the enzymatic activity of these mutants, resulting in reduced levels of 2-hydroxyglutarate (2-HG) and promoting differentiation in affected cells. TQ05310 is valuable for research applications focused on acute myeloid leukemia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2071196-10-4
Applications	IDH2 Mutant Inhibitor
Formula	C₁₉H₁₇F₆N₇O
Molecular Weight	473.37
SMILES	FC(F)(F)C1=CC=CC(C2=NC(NC3=CC=NC(C(F)(F)F)=C3)=NC(NOC(C)(C)C)=N2)=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.