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TR-213

CDK Degrader

TR-213 is a potent molecular glue degrader that specifically targets Cyclin K (CDK). At a concentration of 1 μM, TR-213 demonstrates a significant inhibition of CDK12 and Cyclin levels, leading to decreases of 91% and 56%, respectively. This compound effectively inhibits RNA polymerase II activity and modulates alternative polyadenylation (APA), making it a valuable tool for cancer research and investigations into CDK-related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2980502-40-5
Applications	CDK Degrader
Formula	C₂₂H₂₀N₄O₃
Molecular Weight	388.42
SMILES	N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.