Tracazolate hydrochloride is a potent modulator of the GABAA receptor, specifically exhibiting selectivity towards the β3 subunit. It enhances GABAA receptor activity, demonstrating effective potentiation in α1β1γ2s (EC50=13.2 μM) and α1β3γ2 (EC50=1.5 μM) configurations. With its significant anxiolytic and anticonvulsant properties, Tracazolate hydrochloride serves as a valuable tool for research in neurological and psychiatric disorders, elucidating the role of GABAA receptor modulation in therapeutic contexts.
Tracazolate hydrochloride is a potent modulator of the GABAA receptor, specifically exhibiting selectivity towards the β3 subunit. It enhances GABAA receptor activity, demonstrating effective potentiation in α1β1γ2s (EC50=13.2 μM) and α1β3γ2 (EC50=1.5 μM) configurations. With its significant anxiolytic and anticonvulsant properties, Tracazolate hydrochloride serves as a valuable tool for research in neurological and psychiatric disorders, elucidating the role of GABAA receptor modulation in therapeutic contexts.
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