Fig. 1 · Structure
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Tracazolate hydrochloride
GABAA Receptor Modulator
Tracazolate hydrochloride is a potent modulator of the GABAA receptor, specifically exhibiting selectivity towards the β3 subunit. It enhances GABAA receptor activity, demonstrating effective potentiation in α1β1γ2s (EC50=13.2 μM) and α1β3γ2 (EC50=1.5 μM) configurations. With its significant anxiolytic and anticonvulsant properties, Tracazolate hydrochloride serves as a valuable tool for research in neurological and psychiatric disorders, elucidating the role of GABAA receptor modulation in therapeutic contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1135210-68-2 |
| Applications | GABAA Receptor Modulator |
| Formula | C16H25ClN4O2 |
| Molecular Weight | 340.85 |
| Synonyms | ICI 136753 hydrochloride |
| SMILES | O=C(C1=C(C)N=C(N(CC)N=C2)C2=C1NCCCC)OCC.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.