Fig. 1 · Structure
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trans-Aconitic acid
Aconitase Inhibitor
trans-Aconitic acid is a potent inhibitor of aconitase, functioning both non-competitively to obstruct the conversion of citric acid to cis-aconitic acid and competitively to inhibit the transformation of cis-aconitic acid to isocitric acid. It demonstrates significant biological activity by inhibiting the growth of Leishmania donovani promastigotes and the transformation of amastigotes to promastigotes. Additionally, trans-Aconitic acid affects the in vitro proliferation of Leishmania donovani amastigotes within macrophages, making it a valuable reagent for research on visceral leishmaniasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 4023-65-8 |
| Applications | Aconitase Inhibitor |
| Formula | C6H6O6 |
| Molecular Weight | 174.11 |
| SMILES | O=C(O)/C=C(CC(O)=O)/C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.