Triclosan-13C12 is a stable isotope-labeled form of Triclosan, a potent broad-spectrum antibacterial agent that targets the enoyl-acyl carrier protein reductase (FabI) involved in bacterial fatty acid synthesis. This compound exhibits inhibitory activity against E. coli FabI with IC50 values of 2 μM and 10 μM for the wild-type and FabIG93V variants, respectively. Additionally, Triclosan has been shown to induce apoptosis in cultured rat neural stem cells and to exacerbate colitis and colitis-associated colorectal tumorigenesis in various animal models. This reagent is valuable for studies involving metabolic tracking and the investigation of antibiotic mechanisms.
Triclosan-13C12 is a stable isotope-labeled form of Triclosan, a potent broad-spectrum antibacterial agent that targets the enoyl-acyl carrier protein reductase (FabI) involved in bacterial fatty acid synthesis. This compound exhibits inhibitory activity against E. coli FabI with IC50 values of 2 μM and 10 μM for the wild-type and FabIG93V variants, respectively. Additionally, Triclosan has been shown to induce apoptosis in cultured rat neural stem cells and to exacerbate colitis and colitis-associated colorectal tumorigenesis in various animal models. This reagent is valuable for studies involving metabolic tracking and the investigation of antibiotic mechanisms.
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